Tyson Fury's heavyweight world title rematch with Wladimir Klitschko is to be called off for a second time after the British boxer's Fury's management said he has been "declared medically unfit to fight".
The pair were due to meet in Manchester on 29 October, with Fury defending the WBA and WBO heavyweight belts he took off Klitschko last November.
One attempt at a rematch had already been abandoned because of an ankle injury sustained by Fury and the fight has now been postponed for a second time.
After Fury's injury it then emerged that UK-Anti Doping (UKAD) had charged the champion, over a urine sample taken in February 2015, and his cousin Hughie with a doping offence.
It was alleged the sample - taken nine months before his defeat of Klitschko - contained traces of the banned substance nandrolone.
Fury was provisionally suspended, but that ban has since been lifted, and his legal team said they would be suing UKAD over the allegations. His hearing will be held in November.
Fury was last week due to attend a press conference with Klitschko, but failed to show up, with his manager citing car problems.
"It is with the deepest regret that we have to announce that the world heavyweight championship rematch between Tyson Fury and Wladimir Klitschko, scheduled to take place on the 29th October 2016 at the Manchester Arena, will not be going ahead," a statement read.
"Tyson has, this week, been declared medically unfit to fight. Medical specialists have advised that the condition is too severe to allow him to participate in the rematch and that he will require treatment before going back into the ring. Tyson will now immediately undergo the treatment he needs to make a full recovery.
"We and Tyson wish to express our sincerest apologies to all those concerned with the event and all the boxing fans who had been looking forward to the rematch. Tyson is understandably devastated by the development."