Brazil's Alan Oliveira blew the controversial debate over running blades back open today with a stunning T43 100m world record at the Olympic Stadium today.
And his American rival Richard Browne warned the IAAF, the athletics world governing body, to brace themselves for more legal challenges as amputee sprinters fought for the right to compete at the Olympics.
Oliveira shattered his own T43 double amputee record by winning in 10.57 seconds, with Browne second in the mixed-class race in a T44 world record, for single amputees, of 10.75secs.
Great Britain's Jonnie Peacock, the London 2012 champion, was third in a British record 10.84 as Paralympic fever returned to east London at the Sainsbury's Anniversary Games.
Many of the stars of last summer, including David Weir, Hannah Cockroft and Richard Whitehead, returned with victories to delight a capacity home crowd.
But Oliveira, whose country will host the Olympics and Paralympics in 2016, showed he was the man to take the sport to a new level in the fastest amputee race ever.
Browne, 21, said: "Sub-10 is most definitely possible. If anybody can go sub-10 it's one of the those guys who just crossed the finish line in record-breaking times. If anybody can do it, it's us.
"Oscar (Pistorius) broke down so many doors for us and we all owe him gratitude because he showed the world it's not just crippled people trying to run.
"We will break the able-bodied barrier, to the point where we have it all together.
"There's going to be more than one in the able-bodied Olympics by 2016.
"The IAAF are going to have to be ready. They have no choice - 10.57 - they have no choice but to get ready. They just need to get their rules ready, that's all I'm saying."
"There are no advantages here. If you cut Usain Bolt's leg off, he's not going to go 9.5. I guarantee you. We work harder than anybody in sport. Period" - Richard Browne
Pistorius had to win a lengthy legal battle with the IAAF, going through the Court of Arbitration for Sport, for the right to compete in the Olympics. His Cheetah blades were subject to scientific tests to determine whether they gave him an advantage or not.
Oliveira, 20, wears different blades - their height famously wound up Pistorius last summer - so he would face a whole new fight, always supposing he wanted to pursue the case.
Browne said: "I talk to a lot of the able-bodied guys and they accept us with open arms.
"There are no advantages here. If you cut Usain Bolt's leg off, he's not going to go 9.5. I guarantee you. We work harder than anybody in sport. Period."
Oliveira, speaking through an interpreter, added: "They said we couldn't get 10.5 and I got this. I am going to work harder and harder."
The Brazilian, the Paralympic 200m champion, was rather less forthcoming about whether he might want the chance to compete against able-bodied athletes.
He said: "I want to compete in the Brazilian championships with able-bodied athletes, but I don't think about international able-bodied competition."
Peacock said he was "really annoyed" with his time given he had a 1.9m/s following wind.
But the 20-year-old, a T44 athlete, claimed Browne was getting carried away with his time predictions, saying: "He loves to talk. He's got great talent but I think 10.5 would be a great time for a (single) amputee to run.
"I'm not going to stand here in front of you and say, 'I'm going to run 9.8 next season' because it's not going to happen."
Peacock admitted there was a desire to run in the Olympics, but on whether an amputee could line up in the short sprint in 2016, he said: "In the 100m I don't think you're going to see amputees. You put us next to Bolt and we're going to get absolutely destroyed in the first 20m."
The T43 and T44 classes will be split in future championships.
This was also a day to celebrate for Britain's Paralympic stars, with seven home victories.
Weir, the four-time London 2012 champion, rounded off the weekend with victory in the T54 mile in 3:16.40.
Cockroft repeated last summer's domination by racing away to victory in the T33/34 100m in 17.80.
Whitehead, the some time marathon runner, some time sprinter who memorably roared from the last to first to win last summer, did the same again, blasting through on golden blades to win the T42 200m in 24.86.
Aled Davies, who won Britain's first athletics medal of the Paralympics, triumphed in the F42 shot put, throwing a stadium record 14.31m.
Dan Greaves, who had to settle for silver at London 2012, went one better this time as he won the F44 discus in 57.42m, moments after Graeme Ballard had won the T36 100m in 12.33.
Libby Clegg won the T12 100m in 12.18.