600 healthcare workers will be vaccinated today and tomorrow at Páirc Uí Chaoimh in Cork city.
It is one of five vaccination centres in Co Cork.
People in Group 4 (at a very high risk of severe Covid-19 disease) will receive their vaccinations at the conference centre from Monday.
Like City Hall, the centre has 30 booths and will have the capacity to vaccinate up to 3,000 per day if needed.
Depending on vaccine supply, and demand, the centre could operate seven days a week, 12 hours a day.
The other hubs in the county are located at Cork's City Hall, at the MTU campus in Bishopstown, and at Mallow GAA Club and at Bantry Primary Care Centre.