Taoiseach Micheál Martin has said that the relationship between Ireland and the United States remains one of the strongest and most successful in the world.
Mr Martin was addressing the American Chamber of Commerce Ireland Thanksgiving Lunch in Dublin.
"At a time of turbulence in the global trading environment, it is essential to recognise not only the scale of our economic ties, but also their strategic importance," Mr Martin told delegates.
He said Ireland will work to strengthen and deepen EU-US cooperation during its EU Presidency next year.
Acknowledging the concerns of US companies when it comes to infrastructure gaps, the Taoiseach said that next week the Government will publish an action plan which will recommend significant initiatives to cut through the barriers to infrastructure delivery.
A survey of American Chamber members found that 33% said housing is the number one challenge for Ireland to overcome for their company to invest and expand in the country.
Over four out of five respondents said their corporate headquarters held a positive view of Ireland as an investment or growth location based on the experience of their Irish operations this year.
"We know from our member survey that housing, energy, infrastructure and costs present significant challenges to their ability to grow and expand, with many of these factors ranking above tariffs as the greatest risk to continued US FDI in Ireland over the next five years," said Paul Sweetman, CEO of the American Chamber.
"We recognise the Government's commitment to infrastructure investment in the National Development Plan but again emphasise the need for speed and the removal of the planning barriers to progress," Mr Sweetman said.
According to the American Chamber, employment in US multinationals operating in Ireland has increased by almost 35,000 on this time last year and now stands at 245,000.
