Aer Lingus said its latest new transatlantic route - from Dublin to Indianapolis, Indiana, in the mid-west region of the US - will start on May 3, 2025.
The route will serve as the only direct route between Indianapolis and Europe.
Indianapolis is home to the Indianapolis 500, the biggest single-day sporting event in the world.
The city hosts more than 500 national and international events a year and also sees more than 29 million visitors each year.
The route will be operated by the airline's new Airbus A321XLR aircraft.
"With Indianapolis' vibrant industries and rich cultural heritage, and Dublin's strategic position as a gateway to Europe, this new route will facilitate partnerships and opportunities on both sides of the Atlantic," Lynne Embleton, the Aer Lingus chief executive, said.
"The direct connection will ensure smoother travel for business and leisure travellers while also strengthening cultural and commercial ties between the two regions," the CEO added.
"Reopening a much needed and frequently requested transatlantic route to our dear friends in Ireland will once again open new opportunities for business and leisure alike. It's important that Indiana always keep investing in itself, by letting the world know we're open for business and not even the sky's the limit to our cultivated connections," said Indiana Governor Eric J. Holcomb.
The new Indianapolis route follows the announcement of a new route to Nashville, Tennessee, last month and brings the total number of Aer Lingus routes from Dublin to North America to 19.
Indiana is home to 52 Ireland-based business, and Indianapolis-based Eli Lilly recently invested $1.8 billion in two Irish facilities.
More than 70% of committed capital investment in the state was from foreign direct investment, which underscores the need to continue building non-stop routes.
