Pharmaceutical company Novartis has announced plans to cut up to 400 jobs from its Dublin operations.
The changes will take place over the next two years at its Global Service Centre at Elm Park in Dublin.
The company said the development was a strategic decision and resulted from an ongoing review of its operations in many locations.
It added that the centre will continue to play a critical role, focused on commercial and scientific operations.
"Novartis recognises that announcing such an intention has a significant impact on people and creates uncertainty," it said in a statement.
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"Novartis is committed to keeping associates informed in as transparent and timely a manner, as possible," it added.
Currently, there are around 1,000 people employed at the centre, but this could reduce to 600 over time, it said.
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Employees were informed this morning and a consultation process with employee representatives is to take place.
A spokesperson was not able to say which speciality areas in particular were likely to be targeted by the cuts.
It follows the announcement in April of a new global organisational structure and operating model.
It is aimed at accelerating growth and strengthening the company's pipeline while improving its productivity.
In a statement, Tánaiste Leo Varadkar extended his sympathies to the Novartis employees who have been affected by today's announcement.
"Although the jobs losses are not unexpected, I know it will come as a major blow to workers and their families," he said.
"I'm glad to see that Novartis has reiterated its commitment to Ireland, recognising the high quality of our workforce and that it will keep employees informed in as transparent and timely a manner as possible," he added.
The Tánaiste said he has asked his officials and IDA Ireland to keep him informed of developments.
"Especially regarding precisely how many roles are at risk before the end of 2024 and what the redundancy package will be," he said.
Mr Varadkar said the Government will make all necessary state assistance available, to help the workers find new employment, education and training opportunities.
"Given the nature of the work and sector involved, I would hope they can find new employment quickly.
"Although we live in uncertain times, the Government is doing everything we can to keep the economy in good health and to sustain our current record levels of employment," he added.
Novartis also employs a further 500 people in Cork at a manufacturing plant in Ringaskiddy and at its innovative medicines division in Dublin.
