50 new jobs are to be created by customer experience software developer Concentrix.
The firm has offices in Dublin, Belfast and Derry but the positions will all be remote working roles.
The first phase of recruitment is, however, to be focused in Donegal because it is close to the Derry office.
It also cited the region's skilled workforce, strong education system and robust technology infrastructure for the decision.
"We see great potential in the Donegal region," said Sarah McKay, Vice President of Service Delivery for Concentrix.
"With 160,000 residents and a rich pool of talented, well-educated people who we hope will want to come and join an award-winning international company like Concentrix, we are very excited about moving into Donegal and bringing new flexible employment opportunities to the county."
Globally the company employs 270,000 people, with more than 4,300 working for it in Ireland.
The news was welcomed by the Tánaiste and Minister for Enterprise, Trade and Employment, Leo Varadkar.
"I’m particularly pleased to hear of the flexible nature of these jobs with opportunities to work from home," he said
"Remote working will be a permanent part of life in Ireland after the pandemic, and it’s great to see Concentrix embrace this shift."