Climate activists targeted 15 Amazon depots across Europe on "Black Friday" and the world's biggest e-commerce company also faced protests by workers and delivery drivers in Germany, France and Italy.
Amazon, based in Seattle, is facing criticism from climate activists who say excessive consumption harms the environment.
An alliance of trade unions say the company does not pay workers enough nor enough tax to governments.
"Black Friday epitomises an obsession with overconsumption that is not consistent with a liveable planet," the Extinction Rebellion group said after blocking 13 Amazon depots across the UK.
"Amazon and companies like it have capitalised on our desire for convenience and stoked rampant consumerism at the expense of the natural world," it said.
Reuters reporters at an Amazon depot at Tilbury docks in England said protesters had blocked the entrance. The group also said it had blocked Amazon depots in Germany and the Netherlands.
Extinction Rebellion said Amazon's "crimes" included activities which emitted more carbon dioxide than a medium sized country, helping fossil fuel companies.
Amazon, which brought the traditional US Black Friday discount day to Britain in 2010, said it takes its responsibilities "very seriously".
"That includes our commitment to be net zero carbon by 2040 - 10 years ahead of the Paris Agreement - providing excellent pay and benefits in a safe and modern work environment, and supporting the tens of thousands of British small businesses who sell on our store," it said.
"We know there is always more to do," it added.
Trade unions across Europe's biggest economies also called out warehouse workers and delivery drivers to strike against what they said were Amazon's unfairly low wages and tax payments.
In Germany, the company's biggest market after the US, the Verdi union said around 2,500 employees went on strike at Amazon shipping centres in Rheinberg, Koblenz and Graben.
We need your consent to load this rte-player contentWe use rte-player to manage extra content that can set cookies on your device and collect data about your activity. Please review their details and accept them to load the content.Manage Preferences
In France, one of the country's top labour unions, CGT, called for Amazon workers in the country to go on strike. The union coalition also reported a strike in Italy.
"The coalition demands Amazon pays its workers fairly and respects their right to join unions, pays its fair share of taxes and commits to real environmental sustainability," the "Make Amazon Pay" coalition said in a statement.