Developer Johnny Ronan's company has received planning permission from Dublin City Council for the commercial parts of its Waterfront – South Central scheme in the docklands.
The development involves 66,718 square metres of office space in four blocks ranging in height from five to nine storeys between North Wall Quay and Mayor Street Upper.
In May, An Bord Pleanala rejected plans for two high-rise towers on the site, 45 and 41 storeys tall, as well as a third 14 storey block, that in total involved over 1,000 apartments.
The plan was opposed by An Taisce and environmentalists.
Ronan Group is currently involved in ongoing legal action challenging the Strategic Development Zone rules which cap the height of buildings in the area.
The latest decision by the council to grant permission for the commercial elements of the scheme has been welcomed by the company, which intends to begin construction next year.
"This exciting commercial project will see the development of some of the most enviable office spaces in Dublin city," said Rory Williams, CEO of Ronan Group.
"When complete, workers at the development will have access to unrivalled sustainable transport connections including Luas, DART, Dublin Bus and cycleways."
The development will also feature a pedestrian walkway from Castleforbes Road to North Wall Quay, as well as external terraces, roof terraces and retail and exhibition space.
The company is currently involved in building a new office block nearby for Salesforce, as well as part of the new Facebook campus in Ballsbridge.