Domino's Pizza is set to create 350 jobs across the country, including new management positions, team members and delivery drivers.
The company already employs almost 2,000 staff and contract workers across its 85 Irish stores.
Domino's said these new positions will allow the company to continue to keep their stores open late into the night, to serve local communities.
"It has been a privilege to keep our stores open during Covid-19 and we’re delighted to be able to offer more people the opportunity to become a Domino’s team member," said Scott Bush, CEO of Domino’s Pizza Group, Ireland.
Mr Bush said the wellbeing of team members, contractor drivers and customers is paramount for Domino’s.
"The business has introduced measures such as contact-free delivery and collection in all stores, as well as in car collection in participating stores," he said.
Two weeks ago, the company announced it was taking on 175 additional staff across its operations in Northern Ireland.
Like many fast food firms, Domino's has enjoyed a bounce in sales during the Covid-19 pandemic as restrictions on eating out led more people to eat takeaway food at home.
The company has introduced many measures across its Irish operations to take account of the risks to staff and customers associated with the pandemic.
These include contact free delivery and collection and car collection in some outlets.
Perspex screens have also been installed in all stores and the number of people allowed in each outlet is limited
Domino’s Pizza Group plc holds the master franchise for Domino’s in the Republic of Ireland, the UK, Switzerland, Sweden and Iceland.
It currently has 1,201 stores in Ireland and the UK.