The business sector has criticised the system of mandatory hotel quarantine claiming that not enough consideration was given to the damage it inflicts on peoples' lives and on the economy.
The chief executive of employers' group Ibec Danny McCoy said he had great sympathy for people working on the vaccine roll-out because of the changes that kept occurring.
Mr McCoy also referred to the 16 countries that will come under mandatory hotel quarantine regulations from 4am tomorrow morning. These countries include the US, Canada, France, Italy and Belgium.
In an interview on Today with Claire Byrne, Mr McCoy said foreign companies were asking how the quarantine would impact on business here.
Mr McCoy said pharmacutical, medical and technology businesses all require subject matter experts to come into the country.
In addition, he said, Ireland provides critical and essential software to factories internationally.
He added that queries from senior executives as to 'what is going on in Ireland' have been coming in,particularly since the US was put on the list of countries.
He also said there are issues around people being able to work in hotels while they quarantine because fears around wi-fi security.
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The chief executive of the American Chamber of Commerce has called on the Government to recognise the "particular importance of key global decision makers" and technicians to critical global supply chains in the pharma and med tech industries when it expands the mandatory quarantine list.
Mark Redmond told the News at One that clarity is needed on the length of time countries will placed on Ireland's mandatory hotel quarantine list as well as early clarity on the status of those who are fully vaccinated.
He said that "we need to know if the US is to go on the list, how long it will stay on it" and what are the criteria involved and the review period.
Mr Redmond said that transatlantic connectivity is crucial to US-Irish trade and that there are concerns among US multinationals and for the 650 Irish businesses that operate across the US about the quarantine system.
He said that many businesses that cannot be conducted remotely are often critical ones working in diversified global supply chains.
These include those that supply semiconductor equipment and other advanced manufacturer operations involving workers who ensure that strategy is on track.
He said that the status and importance of those roles need to be borne in mind and the challenge is to match public health needs with keeping important global operations going.
Mr Redmond said "business looks for certainty" and as much as possible Ireland needs to have an evidence-based quarantine scheme that matches best practice so as to protect its reputation as an open economy.