More than 110 jobs are to be lost at two companies with operations in Dublin.
Generic drug maker Viatris is to reduce its workforce in Dublin by around 70 people.
The company announced before Christmas that it was shutting its manufacturing plant in Baldoyle in the capital as part of a global restructuring plan, with the loss of 440 jobs.
Now in an effort to reduce costs further, a further 70 positions are to go in a range of functions at its office on the Malahide Road.
The roles are in areas such as quality and IT.
"The majority of those impacted will remain employed until 2022," said David Delaney, Head of Policy & Market Access, Europe Northern & Western Cluster with Viatris.
"Viatris will now enter into a consultation process with employee representatives."
Viatris was formed by a recent merger between Mylan and Upjohn, which closed in November.
As part of the coming together of the two companies, plans were announced for the generation of savings worth $1.2bn through the consolidation of manufacturing facilities and a reduction of back office positions.
The company is to offer those who are to be made redundant comprehensive redundancy packages, including pay and healthcare continuation, career counseling and continued coverage under the Employer Assistance Program.
"Today's announcement in no way reflects upon the company’s genuine appreciation for the commitment of those impacted and its remaining workforce will continue to play an important role in the company’s future and in Ireland," Mr Delaney said.
Meanwhile, drinks maker Britvic has told staff at its Irish licensed wholesale distribution business, Counterpoint, that it plans to close the firm with the loss of 44 jobs.
The move follows a strategic review of the business which had suffered in recent years from low margins and a contraction of the on-trade.
These were exacerbated by the Covid-19 pandemic which has resulted in the widespread closure of pubs and restaurants.
The firm will now begin a one month consultation period with the staff, who are based at Greenogue Business Park in west Dublin.
"We deeply regret any reduction in employment across our business," said Kevin Donnelly, Managing Director of Britvic Ireland.
"We recognise that this will be extremely difficult for our people who have served the company well over the years. We will do all we can to continue to support impacted employees."
Britvic Ireland's manufacturing business in Ballyfermot in Dublin and Newcastlewest in Limerick, which employ around 400 people, will not be impacted by the decision and the company says it remains committed to Ireland.
Britvic's soft drink brands, including Ballygowan, Club, Britvic and TK Lemonade, will in the future be distributed by third party wholesalers.
In a statement the company said the proposed closure would allow Britvic Ireland to focus on its core competence as a soft drinks brand owner and manufacturer, and exit alcohol wholesaling which is margin dilutive.
"The strategic decision to exit licensed wholesaling and therefore stop selling alcohol is not one we have taken lightly but reflects the need to simplify our business and focus on making, marketing and selling soft drinks," Mr Donnelly said.
