Healthcare provider and insurer UPMC is to create 60 new jobs in Kilkenny over the next three years.
The Pittsburgh based company is to open a global technology operations centre at McDonagh Junction in the city to support its ongoing international expansion.
Recruitment of network, systems and security engineers, security and privacy analysts and other information technology managers has already begun.
"Our multinational business requires a technology platform that allows us to consistently provide the highest quality care at the lowest cost, regardless of location," said Ed McCallister, chief information officer of UPMC.
"As we considered locations worldwide that would best meet our needs, Ireland and its centrally located, multi-cultural workforce quickly rose to the top."
UPMC said it had chosen Kilkenny because it is close to the company's others facilities here, including hospitals, cancer centres and an outpatient site in Waterford, Cork, Carlow and Kildare.
It also referenced the strong tech talent pool, business-friendly environment, significant presence of major tech companies and Ireland's active innovation community supporting tech start-ups.
UPMC currently employs 475 staff here in Ireland and has been operating in the south east since 2006.
The investment is being supported by Government through IDA Ireland and was welcomed by the Minister for Business, Heather Humphreys and IDA boss Martin Shanahan.
"This investment by UPMC demonstrates a huge vote of confidence in Ireland, our strong value proposition and our agile and adaptable business environment that we've sustained despite the unprecedented changes imposed as a result of the Covid-19 pandemic," he said.
"Kilkenny is an ideal choice of location, given the availability of highly skilled creative talent there. The new jobs being created are a welcome boost to the economy of the South East," he added.