Another 100 jobs are to be added to the workforce at the Johnson and Johnson Vision Care Ireland plant in Limerick.
The new jobs are part of a €100m investment at the plant, formerly known as Vistakon, at Limerick's National Technology Park.
The company already employs more than 900 people in Limerick and the expansion is backed by IDA Ireland.
The Limerick unit is the world's largest contact lenses manufacturing plant.
The company said that another 200 people are expected to be employed in the construction phase of its expansion.
John Lynch, plant leader at Johnson & Johnson Vision Care (Ireland), said the company believes the new manufacturing roles being introduced in Limerick this year will be foundational in helping it bring new, innovative contact lens products to its patients and customers around the world.
IDA Ireland's Chief Executive Martin Shanahan said the expansion represents not just a substantial financial investment, but a considerable commitment to its Limerick operations.
He said the 100 jobs being added, along with those being created in the construction phase, will greatly benefit the economy of the midwest region.
"Having a company of this stature continue to expand its operations enhances Ireland's global reputation as a medical technologies centre of excellence and demonstrates how global companies can successfully operate in regional locations," he added.