One hundred jobs are to be created in Dublin by IQVIA, a US firm that provides support services in the pharmaceutical, biotech and medical sectors.
The company is recruiting in the areas of clinical project management, data management, drug safety and biostatistics.
IQVIA says it is seeking pharmacovigilance specialists in particular.
Pharmacovigilance, also known as drug safety, is the pharmacological science relating to the collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products.
With recruitment under way, it expects the jobs to be filled before the end of June.
The jobs will be based at the firm's office in East Point Business Park.
IQVIA, formerly IMS Health and Quintiles, has had a presence in Ireland since 1990. The company employs more than 55,000 people globally
In a statement, the country head for IQVIA Ireland, Martin Giblin, said: "Today’s announcement represents a significant step in increasing our capability to serve our pharma customers across Europe and the world.
"Ireland has a rich base of life sciences talent, is a great place to do business and we look forward to continuing to grow our business here," he added.
The Minister for Finance has also welcomed the jobs.
Paschal Donohoe said: "Ireland’s pharma industry continues to grow and today’s announcement by IQVIA is another exciting development".
Head of Biopharmaceuticals with IDA Ireland Tommy Fanning has also welcomed the announcement.
Separately, 230 jobs are to be created at a plastics factory in Sligo town as part of a global expansion by its American owners.
GW Plastics manufactures injection molding for the medical devices, diagnostics and pharmaceutical industries.