Campbell Soup's chief executive Denise Morrison unexpectedly stepped down on Friday, as the company issued a bleak forecast for the year and said it would embark on a review of its many brands.
Campbell's shares slumped 12%, hitting a more than five-year low and putting them on track for the worst one-day decline since 1999.
Food companies like Campbell have been pressured as consumers increasingly move away from processed food toward healthier options.
The shifting consumer tastes are partly to blame for four straight years of declines at Campbell's US soup business, a period that Morrison oversaw.
Campbell in 2015 reorganised into three divisions, creating the Campbell Fresh unit after combining what was a Packaged Fresh division with soups sold to supermarket delis.
But Campbell Fresh jas struggled, resulting in a two-year decline in organic sales.
Campbell Soup posted a loss of $393m, or $1.31 per share, for the fiscal third quarter ended April 29, compared with a profit a year ago, mainly due to a $619m charge related to Campbell Fresh.
Morrison, 64, departs the company after seven years at the helm. Campbell provided no reason for her departure.
It named board member Keith McLoughlin, 61, a former CEO of vacuum maker Electrolux, as interim CEO.
Chief Financial Officer Anthony DiSilvestro said the company would conduct a critical review of its portfolio over several months.
"Everything is on the table. There are no sacred cows," he said on a conference call with analysts.
Campbell expects to discuss the review outcome when it reports fourth-quarter results in late August, DiSilvestro said in a statement.
Analysts said Campbell Fresh, which sells baby carrots and high-end juices, could be a top priority. The unit had sales of $251m in the third quarter.
"We are all disappointed with the results of C-Fresh, and we acknowledge that they are unacceptable," DiSilvestro said.
Early last month the company announced the Campbell Fresh business would be put within a new accelerator unit focused on driving long-term growth, and headed by Ana Dominguez.
Dominguez, who was previously president of Campbell Canada, is expected to continue in the new position, the person familiar with the matter said.
DiSilvestro blamed tariffs as contributing to Campbell's rising costs.
President Donald Trump announced sweeping tariffs on steel and aluminum to help the domestic steel industry on March 20.
"The issue is primarily one of cost inflation and we're seeing and expecting an acceleration on the rate of inflation across a number of ingredient and packaging items," DiSilvestro said.
"For example, we expect double-digit increases on steel and aluminum. A lot of that is driven or all of it's driven by the impact of anticipated tariffs."
Excluding one-time items, the company earned 70 cents per share, 10 cents above analysts' average estimate, according to Thomson Reuters. Net sales rose 15% to $2.13 billion.