The chief executives of Intel, Merck & Co and Under Armour have resigned from US President Donald Trump's American Manufacturing Council , following Mr Trump's initially tepid response to weekend violence at a rally of white supremacists in Charlottesville, Virginia.
"I resigned from the council to call attention to the serious harm our divided political climate is causing to critical issues...," Intel Chief Executive Brian Krzanich said in a blog post.
Kenneth Fraizer, the chief executive of drug-maker Merck, said he left the advisory council because of the president's reaction after the violence between white supremacists and counter protesters. Mr Frazier cited the need to "take a stand against intolerance and extremism."
The AFL-CIO, a federation of labour unions that represent 12.5 million workers, said it was considering pulling its representative on the committee.
After the white nationalist rally turned deadly on Saturday, Mr Trump initially said that many sides were to blame. Yesterday, in a statement, Mr Trump denounced neo-Nazis and the Ku Klux Klan as criminals and thugs, bowing to mounting political pressure as critics assailed him for not singling out white supremacists.
The CEO of Under Armour, Kevin Plank, announced his resignation from the council in a Twitter posting. "We remain resolute in our potential and ability to improve American manufacturing," said Mr Plank. "However, Under Armour engages in innovation and sports, not politics."
Mr Plank was criticised last winter by some of Under Armour's biggest stars over his support of Mr Trump, comments that basketball star Stephen Curry echoed.
The demonstration in Charlottesville by hundreds of white nationalists took a deadly turn on Saturday when a car ploughed into a group of counter protesters and killed one person.
"America's leaders must honor our fundamental views by clearly rejecting expressions of hatred, bigotry and group supremacy, which run counter to the American ideal that all people are created equal," Mr Frazier said in a statement announcing his resignation.
"As CEO of Merck and as a matter of personal conscience, I feel a responsibility to take a stand against intolerance and extremism," he said.
Mr Trump responded shortly later in a tweet, saying, "Ken Frazier of Merck Pharma has resigned from President's Manufacturing Council, he will have more time to LOWER RIPOFFDRUG PRICES!"
He doubled down on his attack later in the day, tweeting that Merck "is a leader in higher & higher drug prices while at the same time taking jobs out of the U.S. Bring jobs back &LOWER PRICES!"
The son of a janitor, Mr Frazier joined Merck as general counsel of one of the drugmaker's subsidiaries in 1992, working his way up to CEO of the company in 2011.
He made his name as the company's top lawyer, steering it through daunting litigation over Vioxx, its widely used painkiller that was withdrawn in 2004 after being linked to heart attacks.
Many observers thought Merck would eventually have to shell out $10 billion or more to thousands of plaintiffs over the drug's withdrawal. But Mr Frazier's legal strategy led to a $4.85 billion settlement in 2007, allowing Merck to refocus on its pipeline of experimental medicines.
Merck shares closed up 0.5% on the New York Stock Exchange, roughly in line with the wider market.
Mr Frazier frequently made political contributions during the 2016 election, donating to both Republican and Democratic members of Congress but making no donations to a presidential candidate during the year.
The political PAC maintained by Merck and funded through donations from Merck employees made over $1.1 million in candidate contributions during the 2016 campaign - but did not contribute to Mr Trump or his Democratic rival, Hillary Clinton, according to documents filed with the Federal Elections Commission.
The Pharmaceutical Research and Manufacturers of America, which represents the pharmaceutical industry and lobbies on its behalf in Congress, declined to offer a statement of support for Mr Frazier or to comment on Mr Trump’s reaction.
The industry’s silence comes as Trump is finalising an executive order on drug prices that would relax industry regulation and contains measures that, some say, would protect existing drug prices or even increase them.
Individually, at least one CEO, John Maraganore of Alnylam Pharmaceuticals, tweeted his support, saying he was proud to stand with leaders like Ken Frazier.
Other top business leaders also spoke out in response to the violence in Charlottesville.
"I support Ken Frazier’s decision. I’m thankful we have business leaders such as Ken to remind America of its better angels," said Hewlett Packard Enterprises CEO Meg Whitman, who ran for governor of California as a Republican in 2010.
Goldman Sachs CEO Lloyd Blankfein tweeted: "Lincoln: 'A house divided against itself cannot stand.' Isolate those who try to separate us. No equivalence w/ those who bring us together."
Richard Trumka, president of the largest federation of US labour unions, the AFL-CIO, questioned the council's effectiveness and said the group was mulling leaving.
"The AFL-CIO has unequivocally denounced the actions of bigoted domestic terrorists in Charlottesville and called on the president to do the same," Mr Trumka said in a statement.
Several executives from top US companies have previously stepped down from a number of presidential advisory councils in protest to Trump policies.
Tesla CEO Elon Musk and Walt Disney CEO Robert Iger left the President’s Strategic and Policy Forum, a business advisory group, in June, after Mr Trump said he would withdraw from the Paris climate accord. Mr Musk also left the manufacturing council.
Former Uber Technologies CEO Travis Kalanick quit the business advisory council in February amid pressure from activists and employees who opposed the administration's immigration policies.
The White House said Sunday that Trump's remarks condemning violence at a white nationalist rally were meant to include the Ku Klux Klan and neo-Nazi groups.
Democrats and Republicans criticised Trump for waiting too long to address the violence - his first major domestic crisis as president - and for failing when he did speak out to explicitly condemn white-supremacist marchers who ignited the melee.
Mr Trump on Saturday initially denounced what he called "this egregious display of hatred, bigotry and violence on many sides."
On Sunday, however, the White House added: "The president said very strongly in his statement yesterday that he condemns all forms of violence, bigotry, and hatred, and of course that includes white supremacists, KKK, neo-Nazi, and all extremist groups. He called for national unity and bringing all Americans together."