Merck & Co chief executive Kenneth Frazier has resigned from US President Donald Trump's American Manufacturing Council, saying he was taking a stand against intolerance and extremism.
A gathering of hundreds of white nationalists in Virginia took a deadly turn on Saturday when a car ploughed into a group of counter-protesters and killed at least one person.
Trump had said "many sides" were involved, drawing fire from across the political spectrum for not specifically denouncing the far right.
"America's leaders must honor our fundamental views by clearly rejecting expressions of hatred, bigotry and group supremacy, which run counter to the American ideal that all people are created equal," Mr Frazier, said in a statement announcing his resignation.
"As CEO of Merck and as a matter of personal conscience, I feel a responsibility to take a stand against intolerance and extremism," he said.
Mr Trump responded in a tweet, now that "Ken Frazier of Merck Pharma has resigned from President's Manufacturing Council, he will have more time to LOWER RIPOFF DRUG PRICES!"
Several executives from top US companies have stepped down from a number of presidential advisory councils in protest to Trump policies.
Tesla CEO Elon Musk and Walt Disney CEO Robert Iger left the President's Strategic and Policy Forum,a business advisory group, in June, after Mr Trump said he would withdraw from the Paris climate accord. Mr Musk also left the manufacturing council.
Former Uber Technologies CEO Travis Kalanick quit the business advisory council in February amid pressure from activists and employees who opposed the administration's immigration policies.
The White House said yesterday that Mr Trump's remarks condemning violence at a white nationalist rally were meant to include the Ku Klux Klan and neo-Nazi groups.
Democrats and Republicans criticised Mr Trump for waiting too long to address the violence - his first major domestic crisis as president - and for failing when he did speak out to explicitly condemn white-supremacist marchers who ignited the melee.
Mr Trump on Saturday initially denounced what he called "this egregious display of hatred, bigotry and violence on many sides."
Yesterday, however, the White House added: "The president said very strongly in his statement yesterday that he condemns all forms of violence, bigotry, and hatred, and of course that includes white supremacists, KKK, neo-Nazi, and all extremist groups. He called for national unity and bringing all Americans together."
