The Government's annual risk assessment has warned there could be serious damage to the economy if Britain left the EU in a disorderly manner.
It also raised fears about the country's ability to attract and retain investment and jobs arising from changes to US trade and tax policy.
And it noted that corporation tax remains highly concentrated with the top 10 payers contributing close to 40% of this tax.
Climate change is included in this year's risk assessment and it is described as posing very significant challenges.
The report also said technological risks had increased since the last assessment.
"In particular, recent events have highlighted the potential for cyber-attacks, such as that involving the 'WannaCry' ransomware or from data fraud and theft, to cause serious and strategic disruption to important networks or to result in significant negative economic or social consequences.
"The fact that Ireland is home to a large number of international data centres, means that a serious attack or cyber-security failure could have a damaging impact not just on our reputation, but also on our economy, " the assessment found.
Taoiseach Leo Varadkar said the risk analysis can contribute to a "mature debate" about the challenges facing the country.
