The five-star Castlemartyr Resort in Co Cork has been brought to the market by Savills, with a guide price of €13m.
The property is being sold as a going concern and there will be no interruption to business or events booked.
The hotel, on 210 acres of land, incorporates a historic 18th century manor house and is adjacent to a 13th century castle originally built by Strongbow.
The hotel opened in 2007 with 103 bedrooms, including 32 suites and manor state rooms, a spa and health club including a swimming pool, treatment rooms, steam room, sauna, water features and a private treatment suite with infinity pool and sauna.
The resort also features an 18 hole inland links golf course designed by Ron Kirby.
The sale includes 19 golf lodges and a mews house.
"Castlemartyr Resort is one of the finest hotels to ever come to the market in Ireland and provides a buyer with the opportunity to acquire an exceptional hotel in a superb condition," commented Tom Barrett of Savills.
"The significant increase in domestic and overseas trips taken in Ireland has boosted Ireland’s hotel trade and Castlemartyr has huge potential. We expect strong demand from both local and international buyers," he added.