The chief executive of IDA Ireland, Barry O'Leary, is to step down from his role once a successor is in place.
Mr O'Leary has said he would be pursuing other opportunities outside of the organisation.
He said the last few years have been difficult and demanding, and he paid tribute to his colleagues for what he called their "relentless commitment".
IDA client companies created 13,367 jobs in 2013
Separately, IDA Ireland has said its client companies created 13,367 new jobs during 2013, with the net figure standing at 7,071 once job losses were taken into account.
The agency said that this marked the highest level of job creation in over ten years and put total employment across by its client companies above 161,000 for the first time ever.
During the year the IDA secured 164 projects, 78 of which involved companies investing in Ireland for the first time.
The agency said a number of these investments came from high-profile companies like Deutsche Bank and Facebook, however it also secured investments from small but fast-growing companies including Squarespace and Etsy.