Rupert Murdoch's News Corp is leaving the east London location whose name has become synonymous with the revolution which the magnate brought to Britain's media.
In a statement the New York-based media conglomerate said it was pulling its British newspapers from their base in Wapping to a new home in the shadow of The Shard, the capital's tallest skyscraper.
Wapping became the scene of one of the most bitter industrial disputes in recent British history when Murdoch moved his newspaper operation there from its traditional home on London's Fleet Street in 1986.
The surprise move weakened Britain's once-powerful printing unions and laid the foundation for a modernised UK newspaper industry.
News Corp said the move will begin next year.