The American Chamber of Commerce Ireland member companies have over 1,400 jobs vacant job positions, its annual Workforce Activation Survey shows.
The survey also shows that 59% of US companies said they employed more people this year compared to last year, while 75% of respondents said they are currently advertising vacant positions.
Positions currently available include technical and engineering roles, sales and customer support positions and research and development jobs.
Peter Keegan, President of the American Chamber, described the survey's results as encouraging, adding that they point to continued confidence in the multinational sector.
''The quality of Irish graduates is widely recognised and the availability of a skilled workforce is critical to the continued attraction of Ireland as a location for US companies,'' he added.
The survey did highlight some concerns, including the rate of personal taxation here. 53% of respondents said an increase in personal tax rates would impact on potential future expansion plans.
''Ireland has reached a tipping point and is now a high personal taxation jurisdiction which can affect investment decisions and indeed cause our best qualified people to look abroad for opportunities,'' Mr Keegan stated.
''If we want to retain and attract talent, we have to be aware of this effect,'' he cautioned.
The survey also revealed that the majority of participants did not feel that the current international debate on tax has impacted negatively on Ireland's reputation.
It showed that 64% of companies said they were satisfied with the Government's response to the challenges presented by the current tax debate.
''The challenge for Government now is to ensure that Ireland remains attractive to continued investment by foreign direct investors and that it remains competitive across all aspects - tax, talent and cost competitiveness. As a country we need to be planning now to ensure we offset the impact any future changes in international taxation agreements could have on that competitive offering”, Mr Keegan said.