Exploration company Tullow Oil said that its Zaedyus-2 appraisal well in French Guiana had not found any commercial hydrocarbons.
The news dampened hopes of a large new oil field offshore the South American country.
The well, located 5km from the Zaedyus-1 well where oil was struck last year, found oil shows but nothing commercial, Tullow said.
It said reservoirs at the location were not connected to Zaedyus-1 and that the result had no bearing on the bulk of the area yet to be drilled, however.
"The French Guiana block remains highly prospective, particularly down-dip, and still offers excellent potential for multiple exploration successes," the company said in a statement.
Tullow has exploration rights to large swathes of territory offshore French Guiana, Suriname and Guyana, hoping to replicate its success in finding big fields offshore West Africa.
The company believes the regions have shared geology stemming from when Africa and South America were connected many millions of years ago. Tullow has a 27.5% stake in the Guyane Maritime licence and is partnered by Royal Dutch Shell, which holds 45%, and Total with 25%.
