More than 100 people are to lose their jobs at Castleisland in Co Kerry.
US health insurance provider Aetna told staff at its claims processing centre in Castleisland in March that the future of the facility was under review.
Company management said today that it will transfer the work performed in Castleisland to other companies abroad over the coming months and the centre in Castleisland will close by the end of the year.
All 106 staff will be made redundant between now and then.
The announcement follows a decision by the company to outsource its international service operations in six countries, including Ireland.
Aetna has said staff with seven years service could expect redundancy payments of around €18,000.
Dublin and Limerick set for new jobs
Between 100 and 200 jobs are to be created in Dublin and Limerick following the announcement by online fashion retailer Gilt.com that it is to locate its international headquarters in Ireland.
Gilt.com is a US online shopping retailer which provides members with special access to designer brands and merchandise at discount prices.
Founded in 2007, Gilt.com employs 600 people and has more than 3.5 million customers.
Gilt.com is to locate its international headquarters and software development centre in Dublin and a customer support centre in Limerick.
The company hopes to open the Limerick centre by September. The jobs will be split evenly between the two locations.
