Up to 300 jobs are to be lost at a factory in Lisburn, Co Antrim. The US-owned company - Sanmina - is moving production to Hungary. The company makes cabinets for computers and generators.
Sanmina is one of the largest employers in the area and the job losses, although not wholly unexpected, come as a major blow to the local economy.
Rumours that the company was in financial difficulties and under investigation have persisted since initial job losses were announced in December.
Workers have been placed on 90 days notice and talks involving the Amicus union are set to begin immediately.
The Northern Ireland Manufacturing Focus Group has already warned of a potential 30,000 jobs losses over the next five years if the British government failed to take into account the vulnerability of Northern Ireland's manufacturing sector.