The Gossip Girl star fronts the brand’s Lovestruck Floral Rush ad, featuring a male model on a fire escape.
The ad’s premise is similar to Meester’s previous campaign for Wang’s Lovestruck scent.
Meester's Gossip Girl co-star Blake Lively recently debuted her commercial for Gucci Première fragrance, which was directed by Drive's Nicolas Winding Refn.
Meanwhile, Meester starred in this year's Adam Sandler movie That's My Boy, where she played Andy Samberg's fiancée.
Leighton can next be seen in the indie film The Oranges with her former House co-star Hugh Laurie.
