There wasn't a dry eye in the house at the E! People's Choice Awards in Santa Monica on Tuesday night as triple winner Dwayne Johnson gave his People's Champion Award to a Make-A-Wish recipient.

Receiving his People's Champion Award, Johnson first paid tribute to his late friend and inspiration Muhammad Ali.

He then surprised a Make-A-Wish guest named Shushana by inviting her onstage and giving her his People's Champion Award.

"This is a total surprise," he said. "I met her earlier. I told her how inspired I was by her story. She is a survivor. She has fought, literally, for her life. She has inspired her family, her friends. Now, you guys here. Now, the world that is watching.

Dwayne Johnson congratulates Make-A-Wish recipient Shushana

"Muhammad Ali, one of my favourite quotes that he says is, 'The service to others is the rent you pay for the room you have here on Earth'. I want to tell you just how much you've inspired me and everyone around you - and certainly everyone here.

"But, I want to give you this... because you represent everything that it means to be a People's Champion. So this is for you."

"Thank you for this," laughed Shushana. "I didn't expect this at all. Thank you to Make-A-Wish. I just never expected that something this big could happen... This is crazy! I never thought that just from being sick that it could end up in this."

Johnson was also named Male Movie Star of 2021 and Comedy Movie Star of 2021 on a night when BTS, Tom Hiddleston, Scarlett Johansson, Simu Liu and Olivia Rodrigo all enjoyed multiple wins at the awards, which are voted for by the public.

The winners in full:

The Movie of 2021
Black Widow

The Comedy Movie of 2021
Free Guy

The Action Movie of 2021
Shang-Chi and the Legend of the Ten Rings

The Drama Movie of 2021
Cruella

The Family Movie of 2021
Luca

The Male Movie Star of 2021
Dwayne Johnson

The Female Movie Star of 2021
Scarlett Johansson

The Drama Movie Star of 2021
Kevin Hart

The Comedy Movie Star of 2021
Dwayne Johnson

The Action Movie Star of 2021
Simu Liu

The Show of 2021
Loki

The Drama Show of 2021
Grey's Anatomy

The Comedy Show of 2021
Never Have I Ever

The Reality Show of 2021
Keeping up with the Kardashians

The Competition Show of 2021
The Voice

The Male TV Star of 2021
Tom Hiddleston

The Female TV Star of 2021
Ellen Pompeo

The Drama TV Star of 2021
Chase Stokes

The Comedy TV Star of 2021
Selena Gomez

The Daytime Talk Show of 2021
The Ellen DeGeneres Show

The Nighttime Talk Show of 2021
The Tonight Show Starring Jimmy Fallon

The Competition Contestant of 2021
JoJo Siwa

The Reality TV Star of 2021
Khloé Kardashian

The Bingeworthy Show of 2021
Squid Game

The Sci-Fi/Fantasy Show of 2021
Lucifer

The Male Artist of 2021
Lil Nas X

The Female Artist of 2021
Adele

The Group of 2021
BTS

The Song of 2021
Butter, BTS

The Album of 2021
Sour, Olivia Rodrigo

The Latin Artist of 2021
Bad Bunny

The New Artist of 2021
Olivia Rodrigo

The Music Video of 2021
Butter, BTS

The Country Artist of 2021
Blake Shelton

The Collaboration Song of 2021
Stay, The Kid LAROI & Justin Bieber

The Social Star of 2021
Britney Spears

The Pop Special of 2021
Friends: The Reunion

The Comedy Act of 2021
Chelsea Handler: Vaccinated and Horny Tour

The Game Changer of 2021
Simone Biles

The Pop Podcast of 2021
Anything Goes with Emma Chamberlain

The People's Icon of 2021
Halle Berry

The People's Champion of 2021
Dwayne Johnson

The Music Icon of 2021
Christina Aguilera

The Fashion Icon of 2021
Kim Kardashian West