This Friday night, a very special Late Late Show celebrates Daffodil Day, with guest stars including Shane Filan, Jedward and Cavan footballer Oisin Kiernan.
For the second year in a row, the traditional annual Irish Cancer Society fundraiser had to be cancelled, due to the lockdown.
As a result, The Late Late Show is getting behind the initiative and raise vital money to fund the charity's night nursing services, the Irish Cancer Society support line, free counselling services for cancer patients and their families, as well as the 13 Daffodil Centres located at major hospitals across the country.
Westlife star Shane Filan will be in studio, speaking to Ryan for the very first time about how he coped with recently losing both of his parents, Mae and Peter, to cancer, just ten months apart.
Shane will discuss the vital work of the Irish Cancer Society in providing support for patients and families dealing with cancer. He will also share news on Westlife's upcoming plans and perform a Westlife favourite in honour of his parents.
Pop twins Jedward, renowned for their truly outstanding quiffs, will be shaving their heads live on air to help raise Daffodil Day donations.
John and Edward, whose mother Susanna died in 2019 from cancer, said of their upcoming appearance on the show: "We are honouring the memory of all those who have come and gone, we are sending strength and love to all those suffering.
"It's heartbreaking that all our loved ones aren't with us, but they will be looking down on us from heaven."
Cavan footballer Oisin Kiernan will be talking about his diagnosis and treatment for testicular cancer, his subsequent GAA comeback and his advice for young men watching.
Ryan will also meet some of the army of colourful volunteers who swim, run, bucket-shake, drive and cycle each year all in aid of the Irish Cancer Society. CEO of the charity Averil Power will share her own personal experience with the night nursing service.
Plus, band of the moment, Inhaler, will be in studio to perform their latest hit single, Cheer Up Baby. This will be the debut Late Late Show performance for the Dublin quartet.
The Late Late Show, RTÉ One, Friday, March 26th at 9.35pm