Paddy McGuinness says it is strange co-hosting Comic Relief without an audience in the room but admits he just wants people "to enjoy the show".
The annual fundraiser returns to TV screens with appearances from Daniel Craig, Catherine Tate and Olivia Colman.
Top Gear star McGuinness hosts the show, along with Davina McCall, Lenny Henry and Alesha Dixon.
Speaking on Good Morning Britain, the 47-year-old presenter said tonight's set-up is "looking fantastic".
"It’s strange doing the show having no audience or anything else in the room."
He added: "I felt it’s a really tough time for everyone this year. So I just want people to enjoy the show, have a laugh.
"Even though the idea is to raise money, this year, let’s just get together and get around the telly and just relax and smile."
Sketches will include Tate’s foul-mouthed Nan character meeting James Bond, played by Craig.
The show will feature clips from television programmes including The Vicar Of Dibley, Staged and Top Gear.
Jack Whitehall’s Zoom Meeting will see the comedian host a Comic Relief video call, with guests including fellow comedian Guz Khan and actresses Colman and Anya Taylor-Joy.
Normal People and Fleabag will also join forces in a clip for the programme.
The 2021 programme airs on Friday at 7pm on BBC One.
