Moses Boyd, FKA Twigs, Arlo Parks and Flying Lotus were among the big winners at this year's AIM Independent Music Awards.
Due to the ongoing pandemic, the ceremony was held virtually on Wednesday evening.
US producer Flying Lotus won best independent track for More, his collaboration with singer Anderson .Paak.
In response to the win, Flying Lotus said: "It feels like a true blessing to be able to receive an award and to be acknowledged in these times, when they make us feel like our work isn't essential and what we do is just, whatever.
"So thank you for the reminder that what we do is very important."
Boyd was named as the best UK independent breakthrough.
The drummer, composer, producer and former resident DJ on BBC 1Xtra released his debut album Dark Matter earlier this year.
Boyd said: "I'm really privileged for this particular award because I pride myself on being an independent artist and I think it's really important in 2020 that artists coming up understand what it takes to make a product, what it takes to make a record, what's required of an artist.
"I think the industry has changed so much. A lot more control and freedom is being handed back over to creatives, so I think it's important that musicians and artists understand that, and hopefully this can be some sort of inspiration for those trying to follow in the sort of path of the independent artist."
Drummer Sarathy Korwar won the award for best independent album with More Arriving, while singer FKA Twigs picked up the gong for best difficult second album for Magdalene.
FKA Twigs said: "Magdalene is so precious to me, so it really means the world.
"Being an independent artist means every vision is my own and I get to express that, and my label releases without question or judgment."
Singer Arlo Parks won the one to watch award, while Yaeji picked up the international breakthrough award.
Arlo Parks hailed her victory in the one to watch category as a "special day".
The singer, who appeared live in the studio where the virtual ceremony was being recorded, said: "I feel like moments like these so early in my career just feel super, super special and surreal.
"This is a really special day and a really special moment for me and I feel proud to be an independent artist, so thank you very much for this."
Metal band Five Finger Death Punch were named best live act, while the late Afrobeat drummer Tony Allen, who died in April at the age of 79, was previously named as the winner of the outstanding contribution to music award.
At the close of the ceremony Damon Albarn gave a musical tribute to Tony Allen. The Blur frontman and Gorillaz co-creator collaborated with Allen on a number of occasions in The Good, The Bad & The Queen.