Neighbours stars Alan Fletcher and Jackie Woodburne, who play Karl and Susan Kennedy on the show, are set to film scenes in Dublin later this month.
Woodburne is originally from Carrickgerfus, Co. Antrim and is "so delighted to bring cast and crew over to her side of the hemisphere," according to an RTÉ spokesperson.
"We're very excited about Neighbours coming to film in Ireland for the first time ever," the spokesperson added.
"An Irish generation have grown up watching and loving Neighbours and fans here have a very special relationship with it and its characters."
The storyline - which is top secret - will focus on Karl and Susan and will coincide with Neighbours' 35th anniversary.
Neighbours airs weekdays on RTÉ One and RTÉ2. Catch up on Neighbours on the RTÉ Player.
