Will & Grace will come to an end after the show's next season.
The comedy show, with stars Debra Messing and Eric McCormack as the title characters and Sean Hayes and Megan Mullally as friends Jack and Karen, returned in 2017 after originally concluding in 2006.
The upcoming series will be its 11th overall, and the third of the reboot.
Max Mutchnick, one of the show's executive producers, shared a letter sent to the show's team on Twitter, reading: "Today, we informed NBC that this will be the final season of the Will & Grace reboot.
"This decision was made in conjunction with the cast and Mr Burrows (the other executive producer).
"At the end of this year, we will have made a total of 246 episodes of Will & Grace over 11 seasons and 21 years.
"It is our belief that throughout this time, we have been able to sustain a level of quality that we can all be incredibly proud of, especially these past three seasons.
"In the interest of protecting the legacy of this show and the truly outstanding work that went into making every episode, we have decided now is the time to stop."
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Messing said of the decision to bring the show to a close, "We decided it was the right time.
"We were so lucky to have the opportunity to reunite and do the show AGAIN. It was only supposed to be 10 episodes, but because of you, the fans, it has turned into 3 YEARS. What a miracle.
"We are all committed to making this season the best ever, and to wrap up the story of Will, Grace, Jack and Karen in a way that feels meaningful and right."
McCormack added: "Well, we're taking this one out like we brought it in: with love, laughs, gratitude... and on our own terms.
"Season 3 of #WillandGrace(well, season 11) will be our grand finale... and it's gonna be fantastic!"