Bono used U2's concert at Dublin's 3Arena on Monday night to make an appeal to people North and South to look to their future after Brexit, saying "we need more than ever to trust each other on this little island we share".
The appeal came during the encore performance of U2's torch song One, on a night when the message of European unity was often centre stage.
"We're going to say the same thing tonight as we said in Belfast last week," Bono told the crowd.
"That whatever happens, when the dust settles, and the sour taste fades away, whether there is a hard border, or a soft border or no border at all, we need more than ever to trust each other on this little island we share in the North Atlantic Ocean. That's just it."
"There'll be some rough weather ahead, but it will be a lot easier to negotiate if we negotiate it together," he continued.
"We need to be smart, we need to be strategic and we've truly great people representing us on this island at this point in time.
"And they're up for the task, and we wish them the very best in their hard, gruelling work - work that they do not make for themselves."
U2 will play a further three shows at the 3Arena on Tuesday, Friday and Saturday, with bassist Adam Clayton telling Ryan Tubridy on RTÉ Radio 1 on Monday that when the band spoke about Brexit during their recent Belfast concerts they "had an amazing reception there and everyone was very much behind our stance".