Jurassic World velociraptor Blue can be seen causing havoc in the city as the park is replaced by a more downtown setting in the sequel's final trailer.
The footage from Jurassic World: Fallen Kingdom trailer shows Chris Pratt back as Owen Grady and reunited with Blue, the dinosaur he raised and trained.
Taking place four years after the theme park and luxury resort Jurassic World was destroyed by dinosaurs out of containment, Grady has split up from Claire Dearing, played by Bryce Dallas Howard.
Yet the pair are seen returning to Jurassic World to save the dinosaurs, which are under threat from an imminent volcanic eruption.
But they were tricked by a businessman, played by Rafe Spall, who wants to bring the dinosaurs to the mainland and engage as part of a conspiracy that threatens to return the entire planet to a perilous order.
Director JA Bayona has promised the sequel will contain more dinosaurs than ever before.
Jurassic World: Fallen Kingdom is out June 6.