Wonder Woman director Michelle MacLaren has left the movie over creative differences.
The Game of Thrones and Breaking Bad director was confirmed to take the helm of the movie last November.
However, Warner Bros. has now revealed that she has exited the project which stars Gal Gadot as the titular superhero.
The studio said in a statement: "Given creative differences, Warner Bros. and Michelle MacLaren have decided not to move forward with plans to develop and direct Wonder Woman together."
Gadot will make her Wonder Woman debut in Zack Snyder's Batman V Superman: Dawn of Justice which is due to be released on March 16, 2016.
Wonder Woman is reported for release on June 23, 2017.