Grey's Anatomy stars Justin Chambers, Chandra Wilson, Sara Ramirez and James Pickens Jr. have each signed on to star in another two seasons of the hit medical drama.

Should the eleventh and twelfth seasons be commissioned, the four long-term stars of the show will all appear, alongside Ellen Pompeo and Patrick Dempsey who signed similar deals in January.

It has previously been announced that original cast member Sandra Oh, who plays Christina Yang, will leave the show at the end of the current tenth season, with Tessa Ferrer and Gaius Charles also set to depart.