Actress Reese Witherspoon has pulled out of the Nancy Meyers' movie The Intern.

The 37-year-old, who was set to star alongside Robert De Niro in the movie, has decided to drop out.

According to Variety, scheduling was an issue for Witherspoon and sources say Bridesmaids' Kristen Wig may be in the running to replace Reese.

Witherspoon would have played the founder of a successful fashion website who is urged to take part in her company's Senior Intern Program.

A widower and former businessman (De Niro) turns up with a suit and briefcase and the pair end up clashing over business values before he becomes a mentor for the young entrepreneur.

The Intern is set for a 2015 release date.