Shameless creator Paul Abbott has announced that the upcoming 11th series of the comedy-drama will be the last.
The final series will be broadcast next year - 10 years after the series first began filming in Manchester.
In a statement, Abbott said: "Its 10th anniversary seems a fitting time to shut the book on Shameless.
"We've had an absolute ball making this stuff up for a living. We've given back in spades and got away with absolute murder, on behalf of such a fantastically outspoken audience.
"But this is also the year my dad died and he was, in abstract, my core inspiration for starting the whole Shameless party rolling - I wanted to make invisible people vivid.
"Closing the two eras in the same year feels very right. Now I'm off to build the next whatever-it-is."
Channel 4 Chief Creative Officer Jay Hunt said: "Shameless, ground-breaking when it launched and gob-smacking ever since, has over the years built a loyal following.
"We are in Paul Abbott's debt for bringing his defiantly dysfunctional band of characters to Channel 4 and I'm delighted to say we have other drama projects with Paul in the pipeline."