Twink and Blur's Alex James will be among the guests joining Brendan O'Connor on The Saturday Night Show at 10pm.
Twink will be talking about turning 60, her showbiz life and her autobiography.
James will discuss his other career as a cheesemaker and family life in the country.
Also appearing on the show will be Samantha Mumba, who will discuss her upcoming role as Girl Friday in the Gaiety’s Christmas Panto and her engagement.
O'Connor will also be talking to Chris Burch, the stroke survivor who woke up to discover he was gay.
Terry Prone will be discussing her new book about fears and phobias, The Fear Factor, while music on the night comes from Declan O'Rourke.