Bono's motorbike is among the items going under the hammer at a charity auction in December.
The Red Ducati was previously owned by his U2 colleague Adam Clayton and the late Michael Hutchence of INXS.
The proceeds from the sale will go to 'Riders for Health', a group which provides vehicles and safety training for healthcare workers in Africa.
Bono has dedicated the bike to Hutchence, signing the fuel tank: "To Michael, Bono".
Riders For Health chief executive Andrea Coleman said: "Bono's commitment to Africa and his support for those living in poverty and ill-health is well-known. And for us at Riders For Health, reaching those people in rural Africa is our focus and is a major challenge. Riders For Health knows that you can't save a child unless you can reach her.
"Bono's support for our work is valued highly and we thank him."
The auction take place as part of the International Motorcycle and Scooter Show at the Birmingham NEC on 2 December.
