Following their collaboration and onstage kiss at this year's MTV Awards, Madonna is to appear on the first single from Britney Spears' new album.
MTV News reports that 'Me Against the Music' will be sent to US radio stations at the end of the month with the promo video premiering on MTV in October.
Spears debuted the song at a concert to mark the start of the American football season earlier this month in Washington DC.
Her new album, 'Get in the Zone', will be in shops on 18 November and features collaborations with Moby, The Neptunes and Sean 'P Diddy' Combs.