Bono and Pavarotti are to team up on stage next month to raise funds to help Iraqis that have been uprooted by the war.
The United Nations High Commission for Refugees (UNHCR) has confirmed that the Irish rocker and the Italian tenor will sing together at a benefit concert on 27 May in Modena, Italy.
Pavarotti and Bono performed together in 1995 to raise funds for child victims of the war in Bosnia.
Pavarotti has given an annual benefit concert for the past 10 years.
According to a statement, proceeds from this year's event will go to UNHCR's work on behalf of people affected by the Iraq conflict.
UNHCR has set up camps in Jordan, Syria and Iran, which border Iraq.