Bono has paid tribute to a number of musicians including Ed Sheeran, Will.i.am and Mumford and Sons, for highlighting global poverty.
The musicians, who have recorded new versions of celebrated protest songs, will join forces with dozens of singers for agit8 ahead of next week's G8 summit in Northern Ireland.
Agit8 is a campaign to get world leaders to focus on poverty and is backed by the One Campaign, co-founded by Bono.
Bono said: "This week we are reminded of the words of the great agitator Nelson Mandela - 'Like slavery and Apartheid, poverty is not natural. It is man-made and it can be overcome... Millions of people... are trapped in the prison of poverty.
"It is time to set them free... Sometimes it falls upon a generation to be great. You can be that great generation'.
"Since the 1970s, Nelson Mandela has called upon artists and bands to use their platform to fight injustice. We were honoured then, we're honoured now."
Sheeran, who has recorded a new version of Bob Dylan's Masters Of War for agit8, said: "Music is a powerful tool in galvanising people around an issue. There's no better way to get your point across than to put it in a beautiful song."
Other stars enlisted by the campaign include Sting, Elvis Costello, Green Day and Macklemore And Ryan Lewis.
Bono and the One Campaign have also worked with a number of artists including filmmaker Richard Curtis and actor Chiwetel Ejiofor to create a new half-hour film.
The film, which looks at how protest and music has led to change, will be projected on to the side of London's Tate Modern from today.
Watch the videos here one.org/protestsongs and the songs will be available on streaming website Spotify.
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