Super Bowl champions New England went three from three with a 30-14 victory at the New York Jets to continue to set the early pace in AFC East along with the Buffalo Bills.
The Patriots raced into a 20-0 lead in the first quarter as Sony Michel got the first before Tom Brady set up Phillip Dorsett and Julian Edelman. Stephen Gostkowski missed the first extra point but kicked the second and third.
Gostkowski kicked a third-quarter field goal before Rex Burkhead claimed New England's fourth touchdown to take them 30-0 ahead.
Arthur Maulet recovered a punt fumble to get New York back into the game, and when back-up quarterback Jarrett Stidham was intercepted in the fourth, Jamal Adams ran 61 yards for the touchdown - but that was as good as it got for the Jets.
Rookie quarterback Daniel Jones led the Saquon Barkley-less New York Giants on a game-winning drive in the final two minutes in his first career start to defeat the host Tampa Bay Buccaneers 32-31.
Matt Gay missed a 34-yard field goal as time expired to seal the victory for New York (1-2). Gay had made four previous field goals but had missed two extra points, one of which was blocked.
Jones completed 23 of 36 passes for 336 yards and two touchdowns, plus two scores on the ground. Barkley, who hurt his ankle in the second quarter when tackled awkwardly bysafety Mike Edwards, had to be helped off the field. The running back - who had eight carries for 10 yards - was later seen on the sidelines with awalking boot and using crutches.
Buffalo were pushed all the way in Cincinnati and were indebted to Frank Gore, whose one-yard touchdown late in the game sealed the 21-17 win.
The Miami Dolphins prop up the AFC East after a 31-6 loss to the Dallas Cowboys took their start to the season to three straight defeats.
Dak Prescott combined twice with wide receiver Amari Cooper for scores before getting a touchdown of his own as Dallas dominated in Florida.
Jared Goff passed for 269 yards and two touchdowns as the Los Angeles Rams shook off a slow first half to remain undefeated by beating hosts Cleveland 20-13.
The Browns had a chance to tie the game after a Juston Burris interception ofGoff with 2:54 remaining, but a potential 57-yard drive fell 4 yards short when Baker Mayfield's pass on fourth down was intercepted in the end zone by Rams safety John Johnson with 27 seconds remaining.
Kansas City head the AFC West after a hard-fought 33-28 victory at Baltimore.
A Mark Ingram touchdown gave the Ravens an early lead but the Chiefs hit back and after going in front were never headed.
But from 23-6 ahead in the second quarter, they had to hold off a spirited Ravens side as quarterback Lamar Jackson scrambled for a late touchdown to bring his side to within five points.
Indianapolis Colts made it two wins from two as the AFC South outfit defeated the Atlanta Falcons 27-24.
Over in the NFC North there were wins for Green Bay, Detroit and Minnesota.
The Packers defeated the Denver Broncos 27-16, the Lions edged past the Philadelphia Eagles 27-24 and the Vikings were 34-14 winners over the Oakland Raiders.
Teddy Bridgewater threw two touchdown passes in his first start in place of Drew Brees as New Orleans won at Seattle.
Bridgewater was making his second NFL start since the 2015 season as he fills in for Brees. The former Pro Bowl quarterback completed 19 of 27 passes for 177 yards.
He hit running back Alvin Kamara on a 29-yard touchdown late in the second quarter and wide receiver Michael Thomas from 1 yard out in the third.
Kyle Allen threw two of his four touchdown passes to tight end Greg Olsen as the Carolina Panthers notched their first victory by defeating hosts Arizona Cardinals 38-20.
Deshaun Watson connected with tight end Jordan Akins for two second-half touchdowns to lead Houston to a come-from-behind 27-20 victory over the Los Angeles Chargers at Carson, California.
Watson escaped the grasp of Melvin Ingram and hit Akins for a 53-yard scoring play with 9:40 left in the fourth quarter to make it 27-17.
Jimmy Garoppolo's 5-yard touchdown pass to Dante Pettis with 1:15 left boosted the error-prone San Francisco to a 3-0 start as they rallied past winless Pittsburgh in a 24-20 victory.
Garoppolo completed 23 of 32 passes for 277 yards with two interceptions. TheNiners won despite making five turnovers and committing 71 yards worth of penalties.