France will be without both Franck Ribery and Clement Grenier for the World Cup, manager Didier Deschamps has announced.
Bayern Munich winger Ribery, Les Bleus' star man and a player with 80 caps to his name, has been struggling with a back problem for several weeks.
Having followed an individual training programme, he was due to rejoin the full squad on Friday in a bid to prove his fitness.
But Deschamps announced that both Montpellier winger Remy Cabella and Southampton midfielder Morgan Schneiderlin had been called up from the reserve list to replace Ribery and Lyon midfielder Grenier, who has been ruled out of the trip to Brazil with a thigh problem.
"This morning before the collective training session... he had to stop, the pain was too strong," Deschamps said.
"We have made checks in the beginning of the afternoon, checks that confirmed the situation has aggravated and he is today not capable of training for a few weeks, let alone play a game."
The replacements have to be validated by world governing body FIFA as they are made after the 23-man squad submission deadline, which was on 2 June.
"We will hand over those two files and they will take the time they need to reply," said Deschamps.
"They are the first, Franck or Clement, to be very sad. Franck had problems but everything was going in the right direction until his situation suddenly aggravated."
Deschamps had already been forced into one change to his original squad, with injured Marseille goalkeeper Steve Mandanda replaced by St Etienne's Stephane Ruffier.
France will play in Group E along with Ecuador, Switzerland and Honduras.