Portugal central defender Pepe will miss their opening 2022 World Cup qualifiers after picking up an injury playing for his club Porto.
Pepe, 38, limped off midway through the first half in second-placed Porto's 2-1 Primeira Liga win at Portimonense on Saturday which kept them 10 points behind Sporting Lisbon. The latter's Luis Neto has been called up as a replacement.
Portugal, who are in the Republic of Ireland's qualifying group begin their quest to make Qatar next year with a 'home' game against Azerbaijan in Turin on Wednesday next, before they visit Serbia on Saturday. Three day later, the European champions will travel to Luxembourg.
Follow Serbia v Republic of Ireland via our live blog on RTÉ.ie/sport and RTÉ News app, watch live on RTÉ2 and the RTÉ Player or listen to commentary on RTÉ 2fm's Game On