Gareth Bale was left out of the matchday squad as Real Madrid claimed a hard-fought 3-2 win over Villarreal at the Bernabeu on Sunday.
Despite Karim Benzema being ruled out through injury, Bale was deemed surplus to requirements by head coach Zinedine Zidane, fuelling speculation that the Welshman will leave Madrid in the summer.
In his absence, Real took the lead after just two minutes when Santi Cazorla was caught in possession and Brahim Diaz nipped in to tee up Mariano, who got between two defenders to stab home.
The impressive Gerard Moreno equalised just nine minutes later but Real went back in front through Jesus Vallejo's close-range finish shortly before the interval and Mariano tapped in from Dani Carvajal's superb low cross early in the second half.
Villarreal created numerous chances but it took until the last few seconds of added time before Moreno set up Jaume Costa on the edge of the area to curl a superb left-foot shot into the top corner.
Getafe took a major step towards securing Champions League football for the first time in their history with a comfortable 2-0 win over 10-man Girona.
Jorge Molina opened the scoring after 16 minutes with a right-footed shot which went in off the far post and Girona's hopes of a comeback suffered a major blow in the 69th minute when Borja Garcia was shown a straight red card for dissent after being denied a free-kick.
Getafe made the most of their numerical advantage eight minutes later when substitute Angel Rodriguez doubled their lead with a low finish into the bottom corner.
A miserable day for Girona saw them drop into the relegation places thanks to Real Valladolid's 1-0 win over Athletic Bilbao, Waldo Rubio's stunning strike from the edge of the area giving Real all three points.
And that result also meant Rayo Vallecano and Huesca were both relegated from LaLiga, Rayo having lost to Levante on Saturday and bottom side Huesca thrashed 6-2 at home to Valencia on Sunday.
Daniel Wass opened the scoring after two minutes and Rodrigo Moreno and Santi Mina both grabbed a brace as Valencia raced into a 6-0 lead with the aid of an own goal from Xabier Etxeita.
Gonzalo Melero pulled one back on 66 minutes and Alex Gallar converted an injury-time penalty, but it was too little, too late for the home side.
Elsewhere, Eibar solidified their position in mid-table with a 1-0 win over Real Betis, Jose Angel rifling in a low drive straight from the training ground after Fabian Orellana had pulled back a corner to the edge of the area.
Betis squandered their best chance of an equaliser when Giovani Lo Celso's penalty midway through the second half was struck straight down the middle and saved by the legs of goalkeeper Marko Dmitrovic.