Levadia Tallinn v Dundalk, Kadriorg Stadium, 5pm
Dundalk are the only seeded Irish side in this year's Europa League as they visit Estonia for the first-round first-leg tie.
The Lilywhites will fancy their chances against the side beaten by Cork City twice last year, but they have tried to revitalise their squad so there is something of the unknown as well.
But goals will be at the forefront of the SSE Airtricity Premier Division leaders' mind.
Stephen O'Donnell is out with a broken leg while Stephen Folan has a knee injury. Dean Jarvis has a hip flexor injury and Michael Duffy has a groin problem with both being rated doubtful for the encounter.
Stephen Kenny: "We have a very tough game ahead of us. We have a battle to win. We have to earn the right to get the victory. There's a real determination to go and win the game.
"We are on a terrific run at the moment with 10 straight victories (in the league). Levadia are having a good season. They are a good side but we want to win and we intend to do so.
"We are here to do a job. There has been big changes this year with Levadia - they have a lot of new players and a new Serbian coach. They are a good team. They are a very attacking team. They seem to really attack with four forwards.
"It is set up for a very interesting game overall. Levadia are a very well drilled and structured team so we will have to earn the right to win."
Derry City v Dinamo Minsk, The Brandywell, 6pm
As usual, Derry have been given a difficult draw as a Belarusian side with one defeat in 16 minutes mark the return of European football to the venue.
Ally Roy, Dean Shiels, Aaron Splaine, Ben Fisk and Danny Seaborne have all joined City recently to boost their squad after a dire run in the league.
This is a huge test and a big ask.
Nicky Low is definitely out and Gavin Peers is a doubt
Kenny Shiels: "We’re returning to the European stage on Thursday night and that’s a very positive occasion for the whole club. We have new players in and a very young squad who have worked so hard to get us here.
"They need our supporters; we all do. I sincerely hope that every single person who is able to, will come to the game and back us."
"Dinamo Minsk are a quality side and we definitely have our work cut out in both games. I will be asking a lot of the players to ensure that we do everything we can to make this a memorable occasion."
"I just really hope that our supporters do everything they can to back us."
Shamrock Rovers v AIK, Tallaght Stadium, 7:05pm
The Hoops have been improving in the league but this is going to be a challenge against a seasoned European side. Keeping a clean sheet will be a big priority with a big crowd expected in Tallaght Stadium.
Brandon Miele suffered a knee injury in training and will be out for three or four weeks. Sean Boyd also remains out.
Stephen Bradley: "We've been excellent as of late, we've lost one in nine. The lads have worked really hard and they're playing well and keeping clean sheets. We'll need all that on Thursday because we're up against a really good side.
"We'll have a look at what [formation] suits us best and make the decision accordingly. The players are very comfortable playing either three or four at the back so it's not a big issue any more.We know a good bit about AIK, we've done our homework on them. We've had a lot of reports and had them watched.
"Stephen McPhail was over there at the weekend as well. We know it's going to be a tough game for us but it's one we're looking forward to.
"I believe 100% we can cause them problems and the group believe that. We've watched them play, we've watched the videos and we know we can cause them issues. But we also understand that they're a really good side."