Gordon D'Arcy has been ruled out of the remainder of the RBS 6 Nations Championship with a foot injury.
D'Arcy was experiencing some discomfort in his right foot following the game against England and following a scan yesterday afternoon, it was confirmed that D'Arcy has a stress injury to a bone in his foot.
The centre will not be able to return for at least six weeks pending further tests and specialist review.
The Ireland training squad for the Scotland match week will be announced on Sunday evening following the completion of games in the RaboDirect Pro12.
Ireland have already lost wing Simon Zebo (foot) for the rest of the tournament, while fly-half Jonathan Sexton (hamstring) and lock Mike McCarthy (knee ligament strain) will also miss the game at Murrayfield on 24 February.
D'Arcy's injury means that Ireland coach Declan Kidney will need to make at least five changes for the trip to Edinburgh.
On top of the injuries to D'Arcy, Zebo, Sexton and McCarthy, prop Cian Healy is suspended after he was cited for stamping on England prop Dan Cole at the Aviva Stadium.
Ireland currently lie fourth in the table with one win from two games.
After the Scotland fixture, Declan Kidney's men host France on 9 March and then tackle Italy in Rome seven days later.